Colorectal tumors that underwent somatic next-generation sequencing (NGS) for 154-168 genes in an in-house laboratory between 2015 and 2022 were retrospectively identified. Microsatellite instability ...

Somatic mutations are changes to the DNA sequence that arise in non-reproductive cells during a plant’s lifetime, generating genetic mosaicism within leaves, stems and roots. In plants, the absence of ...

At the American Society of Clinical Oncology (ASCO) annual meeting, updated data on the use of olaparib (Lynparza) in patients with metastatic breast cancer (MBC) with somatic BRCA1/2 and germline ...

In this Innovation Spotlight, Peter Campbell, the cofounder and chief scientific officer of Quotient Therapeutics discusses a new somatic genomics platform built to identify these mutations and ...

Two months later, Gould began to experience a strange cascade of symptoms. His ankles swelled to the width of his calves. The right side of his face became so bloated that he could not open his eye.

Dr. Evan Yu presents the new evidence-based guideline on genetic testing for metastatic prostate cancer. He discusses who should receive germline and somatic testing with next-generation sequencing ...

Scientists already suspect that somatic mutations—those that accrue in cells outside the germline over a person’s lifetime, seemingly at random—play a role in neurodegenerative diseases. Now, several ...

A man in his early 80s presented with transfusion-dependent macrocytic anaemia, steroid-responsive headaches and recurrent inflammatory flares. Broad infectious, autoimmune and haematological ...