A study reports for the first time on the importance of post-translational modification by neddylation in postnatal brain development. In particular, it is critical to synapse maturation and stability ...

Neddylation drives liver disease to induce the development of hepatocellular carcinoma. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews ...

Professor Yi Sun's team at the Zhejiang University reported a functional compensatory effect between the Ube2m-Rbx1 and Ube2f-Sag axes of the neddylation-CRLs system in Treg cells, using conditional ...

Small cell lung carcinoma (SCLC) is a highly lethal, metastasis-prone solid tumor that is difficult to treat with standard therapies. While SCLC is often initially responsive to combination ...

Researchers from the Basque Center for Cooperative Research in Biosciences (CIC bioGUNE) have demonstrated that inhibiting posttranslational modification of proteins with NEDD8, a process called ...