The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a ...

Researchers have developed a novel method for simultaneously recording action potentials (APs)—temporary changes in electrical potential when cells become excited—and calcium transients—calcium ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

New mechanism found: Researchers discovered that statins can bind to and activate ryanodine receptors in muscle cells, potentially explaining muscle pain in some patients. Why it matters: Uncovering ...

Calcium does more than strengthen bones; it supports muscles, nerves and mood. Discover the warning signs of deficiency and ...

The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study. The flow of water within a muscle fiber may dictate how quickly muscle can contract, ...

While calcium is most often thought of in the context of building strong bones and teeth, its role in the body extends far ...