Working at the interface of developmental biology, physiology, health and disease, our researchers utilize diverse disease models to understand the biology of human diseases that can impact all stages of life -- from hereditary and congenital birth defects ...

Descriptions of the embryo go back at least to the time of Aristotle, but it has only been since the late 19 th century and early 20 th century that advances in experimental approaches allowed scientists to interrogate how these cells develop. 1,2 ...

Genetically-humanized FcRn mice provide translational pharmacokinetics (PK) and pharmacodynamics (PD) data for antibody-based therapeutics. The image illustrates a therapeutic antibody (blue) adhering to its target cell surface. [The Jackson Laboratory ...

The drug development industry has grown into a troubling duality—one characterized by scientific progress and pervasive failure. Decades of technological advancements have enabled the precise engineering of novel compounds against an ever-growing range ...

Human disease can impact all stages of life -- from hereditary and congenital birth defects to the degenerative diseases of old age -- as well as any of the organs or systems in the human body. Research in the Development, Disease Model and Therapeutics ...