Human genomes exhibit segmental copy number variation (CNV) at thousands of loci. Rare and de novo deletions and duplications, which are often large (hundreds of kilobases in length), are known risk ...

Using whole genome sequencing, copy number signatures were successful in predicting both the presence of chromothripsis and clinical outcomes in patients with newly diagnosed multiple myeloma (MM).

DigC Is Designed to Analyze CNV in a Single Cell The analysis of copy numbers of genetic sequences is of fundamental importance in biology and medicine, and Digital Counting (DigC) is a new method to ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

The use of cell-free DNA (cfDNA) obtained from maternal plasma to perform noninvasive prenatal screening has been rapidly integrated into the care of pregnant women who are at high risk for fetal ...

Understanding the relationship between mtDNA and animal growth could provide valuable information for selective breeding in aquaculture. However, the complex interactions between genetics and ...

Parents' Experiences With and Preferences for Receiving Information About Tumor Genomic Sequencing: Findings From a Qualitative Study and Implications for Practice For a 2-year overall survival end ...

Young, Empowered and Strong: A Web-Based Education and Supportive Care Intervention for Young Women With Breast Cancer Across the Care Continuum To overcome these challenges, we have developed a ...