LaBonne is president of the Society for Developmental Biology and the Erastus Otis Haven professor of molecular biosciences at Northwestern University. Imagine a world without lifesaving medicines, ...

Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

The U.S. Food and Drug Administration’s recently published Roadmap to Reducing Animal Testing in Preclinical Safety Studies may have caused a stir across the pharmaceutical and biotech industries, but ...

CRISPR-Cas9 technology is used to knock out or modify DNA in research mice to study disease phenotypes and develop new treatments. CRISPR mice and rats are offered by Charles River, which uses genetic ...

Animal models continue to be a mainstay of basic research and preclinical studies. But since animals such as mice only approximate humans, they may generate findings of limited clinical relevance.

In this whitepaper, Sartorius discusses the need to replace animal testing with advanced in vitro human cell models for pharmaceutical, chemical, and cosmetic development as, with only 5-10% of ...

A team of UC Davis Health scientists has developed a new predictive model that translates cardiac research findings across different animal species into human-specific insights. This model could help ...